Methamphetamine (MA) is a highly addictive stimulant responsible for 8-10% of all addiction treatment admissions in the USA. Research concerning the acquisition of MA addiction has been neglected in favor of modeling late-stage addiction. Given that not many users reach late stage addiction, the neurobiological factors of the reward circuit that contribute to this initial acquisition of MA addiction are important to understand. The nucleus accumbens (NAC) comprises part of the reward circuit that drives our motivation in behavior. It is divided into two subregions, the core and the shell, which previous studies suggest hold opposite functions in MA-taking behavior. They receive input from the prelimbic and infralimbic subregions of the ventromedial prefrontal cortex (vmPFC), which define four different subcircuits that may be involved in MA preference and motivation. Beginning with the prelimbic-core subcircuit, we propose that by increasing its activity we can drive the mice’s MA-taking behavior, while by decreasing its activity, we can reduce this behavior when compared to controls. Using a dual virus chemogenetic approach, we effectively control the activity of the prelimbic-core subcircuit in B6 mice as they undergo MA-induced operant conditioning procedures. If the mice do acquire the MA addiction behavior within a 14-day threshold, we will measure their desire for MA by increasing the amount of nose-poking behavior they must perform in order to receive the drug. Alternatively, if decreasing the activity of the circuit impairs acquisition, the animals will be euthanized and their brains removed for immunohistochemical analyses to determine if the prelimbic-core subcircuit was, in fact, manipulated. These findings will give insight on the role of this subcircuit in addiction vulnerability and aid in the development of addiction treatment to help a greater array of individuals.