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The goal of this project is to identify the characteristics and methods needed in order to optimize efficient hydrophobic drug delivery via lipid nano-carriers. The hydrophobic drug, pacitaxol, is cancer therapy drug which inhibits the mitosis by stabilizing the microtubule structures during metaphase. The current focus of this project is to increase drug loading and effective delivery inside cells by determining the optimal lipid composition and physical characteristics of the liposome nanocarrier. During my RET 1 experience, I engaged in methods including the fabrication of liposomes, testing various liposome compositions on cells using viability assays, microscopy and the evaluation of the physical properties of such nanoparticles.
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RET Presentation.pdf | 2.17 MB |
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This portfolio includes five lesson designs with corresponding materials that may be used to incorporate active learning by way of student website creation into your classroom. Students will engage in unit and quarterly capstone activities that will be documented in their student created websites. The activities become primarily student directed with guidance provided by my model website which explains formal expectations and grading policies. Though my model website unit writing prompts (per each unit of study) are directly related to my Medical Chemistry course, the student website design and purpose can be used for any science course. The lessons are designed to gradually build science literacy skills and put scientific research into practice while gaining understanding of chemical concepts as related to the health field and medical technologies. In the final lesson they build their “Exploration Page” in which they will put their newfound skills and understanding of science into use as they engage in a group think-tank activity inspired by the ExploraVision National Competition.
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RET Portfolio L.Galvin 2:24:17.pdf | 4.95 MB |